Dr. Michele Hargittai
Assistant Professor
Sullivan 310
Phone: (814) 472-2775
Email: MHargittai@francis.edu
Education:
B.S. in Chemistry, Illinois State University
Ph.D. in Biochemistry, Molecular Biology, and Biophysics, University of Minnesota
Postdoctoral Research Associate, Pennsylvania State University
Office Hours:
Monday: 1:00pm - 3:00 pm
Thursday: 10:00pm - 12:00 pm
Courses Taught:
CHEM 103 Human Chemistry 1
CHEM 104 Human Chemistry 2
Research Interests:
Viral replication
Mitochondrial Transcription
Publications/Awards:
1. Hargittai M. R. S., Cameron C. E., The Hepatitis C Virus NS5A protein inhibits PKR activation. in preparation
2. Hargittai M. R. S, Hwang J., Cameron C. E., PKA phosphorylation regulates nuclear localization of the Hepatitis C Virus NS5A protein. in preparation
3. Pathak H. B., Arnold J. J., Wiagand P. N., Hargittai M. R. S., Cameron C. E., Picornavirus genome replication: Assembly and organization of the VPg uridylylation ribonucleoprotein (initiation) complex. (2007) J Biol Chem, 282, 16202-16213.
4. Huang L., Hwang J., Sharma S. D., Hargittai M. R. S., Chen Y., Arnold J. J., Raney K. D., Cameron, C. E. Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein. (2005) J Biol Chem 280, 36417-28.
5. Huang L., Sineva E. V., Hargittai M. R. S., Sharma S. D., Suthar M., Raney K. D., Cameron, C. E. Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli. (2004) Protein Expr Purif 37, 144-53.
6. Hargittai M. R. S., Gorelick R. J., Rouzina I., Musier-Forsyth K.Mechanistic Insights into the Kinetics of HIV-1 Nucleocapsid Protein-Facilitated tRNA annealing to the Primer Binding Site. (2004) J Mol Biol 337, 951-68.
7. Hargittai M. R. S., Mangla A. T., Gorelick R. J., Musier-Forsyth K. Terbium Cleavage Assays Reveal tRNALys,3 Structural Changes Induced by the HIV-1 Nucleocapsid Protein. (2001) J Mol Bio 312, 985-97.
8. Hargittai M. R. S., Musier-Forsyth K. Use of Terbium as a Probe of tRNA Tertiary Structure and Folding. (2000) RNA 6, 1672-80.